Though his best-selling novel of school life Eric, or, Little by Little: A Tale of Roslyn School has over the years been the subject of much attention, the wider educational thought and practice of Frederic William Farrar, teacher, novelist, scientist, classicist, theologian, and Dean of Canterbury, has for the most part been neglected by scholars. This paper discusses certain aspects of Farrar the educationist, including his distinctive evangelical attitude toward children; his fervent criticism of the prevailing Classical public (...) school curriculum; his advocacy that much more science be taught; his strong antipathy to corporal and other punishment; his distaste for the increasing athleticism in the public schools; his view of the main purpose of education, namely the inculcation of morality, religious conviction, and intellectual rigor. (shrink)

This article examines what light new developments in the history of books and reading can shed on the sixteenth-century antiquarian William Lambarde and his assessments of the credibility and historicity of the ancient past. It explores what the retracing of a book’s life cycle—i.e., its travels from composition and revision to reception, via both manuscript and print—can teach us about Lambarde’s magnum opus, his Perambulation of Kent. Specifically, it surveys how both Lambarde and his contemporaries approached one of the (...) most hotly contested questions in early modern scholarship: debates over the ostensible Trojan origins of the British. The article begins by examining links between the history of reading and the history of antiquarianism—two fields which have enjoyed a considerable efflorescence in recent decades. It does so via re-examination of Arnaldo Momigliano’s classic essay ‘Ancient History and the Antiquarian’, published nearly seventy years ago in this Journal. It then examines how not only Lambarde himself, but also various other contemporary or near-contemporary scholars and readers approached the historicity of Britain’s ancient past, whether Trojan or otherwise. The following section explores the ways in which scholars and readers, including Lambarde, construed the fides or credibility of claims concerning such pasts, by dissecting their various strategies for assessing and visualising textual authority and authorial probity, ranging from the production of marginalia to index-making. This section includes an extended case study of the way in which one assiduous reader of Lambarde—Adam Winthrop, father of the future Massachusetts governor John Winthrop—applied these strategies in his copiously annotated copy of the Perambulation. The article closes with broader reflections upon new directions in the history of historical scholarship and the history of reading. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Authenticity, Antiquity, and Authority: Dares Phrygius in Early Modern EuropeFrederic ClarkDares Phrygius, “First Pagan Historiographer”In his Etymologies, Isidore of Seville—the seventh-century compiler whose cataloguing of classical erudition helped lay the groundwork for medieval and early modern encyclopedism—offered a seemingly straightforward definition of historiography, with clear antecedents in Cicero, Quintilian, and Servius.1 Before identifying historical writing as a component of the grammatical arts, and distinguishing histories from poetic fables, Isidore (...) confirmed that “history is a narration of deeds [narratio rei gestae], through which things done in the past are discerned.”2 Thereafter, he equated historical writing with eyewitness observation, insisting that “among the [End Page 183] ancients, no one wrote history unless he had been present and seen those things to be recorded.”3 But Isidore’s further treatment of historiography grew more perplexing. Upon affirming that “among us, Moses first composed a history, on the beginning of the world,” he unexpectedly declared that “among the pagans, Dares Phrygius first composed a history, concerning Greeks and Trojans.”4 Only later did the encyclopedist mention more well-known Greek historians (to modern audiences at least) like Herodotus. 5Isidore’s invocation of his “first pagan historiographer” referred most likely to the De excidio Troiae historia (henceforth DET), a fifth- or sixth-century Latin pseudo-history billed as an eyewitness account of the Trojan War. Conveyed in sparse, dry, and inelegant language, the DET was long thought to have been the war diary of one Dares Phrygius, purportedly a Trojan participant in the conflict.6 In reality, the Latin DET was a two-part forgery, as its spurious dedicatory epistle—supposedly from the Augustan-era biographer Cornelius Nepos to the historian Sallust—claimed that “Nepos” had discovered the work in an Athenian archive and rendered it “truly and simply” (vere et simpliciter) from Greek into Latin.7 While potentially derived from a Greek antecedent, perhaps composed as an anti-Homeric jeu d’esprit during the Second Sophistic, the Latin Dares was assuredly not an accurate and verbatim translation of any lost Greek original. 8Notwithstanding its uncertain origins, Isidore’s pagan counterpart to Moses would go on to achieve canonical status in the medieval Latin West, and survives today in approximately 200 manuscripts. Moreover, Dares’s authority was extended through practices of compilation integral to medieval [End Page 184] textual culture.9 This compilatory impulse—which spawned countless multi-text anthologized codices and similarly animated Isidore’s encyclopedism—encouraged the Phrygian’s codicological pairing with numerous sources both ancient and medieval. Not only did the DET serve, codicologically, as a prologue to Trojan origin narratives like Geoffrey of Monmouth’s Historia regum Britanniae, but it was also integrated into the structure of universal history, utilized as a means of augmenting the Chronicon of Eusebius-Jerome.10 Throughout the Middle Ages, Dares served not only as a name to invoke, but also as a source to appropriate and rework: to insert into universal chronicles, append to Trojan genealogies, or render into epic verse. Moreover, the pseudo-author’s status as “first pagan historiographer” was hardly lost on medieval sources: for instance, when William of Malmesbury inserted the DET into his anthology of ancient Roman histories, he made sure to include Isidore’s endorsement directly before the text’s incipit.11 For nearly a millennium, Dares’s fabricated claims of antiquity and autopsy constituted airtight guarantors of textual auctoritas.Between Criticism and Credulity: Dares in Early Modern ScholarshipBut Dares did not remain undisturbed in the canon. Instead, the DET saw its first recorded challenge with the advent of the early Renaissance. Writing in 1400 in his De tyranno, the Florentine Chancellor Coluccio Salutati turned to the Phrygian when debating a favored subject of nascent Italian humanism—the history of early Rome. Here Salutati sought to counter the long-held claim, attested in the DET, that Aeneas was not a pious hero driven from Troy, but rather a duplicitous traitor who had himself betrayed the city to the Greeks.12 The Florentine Chancellor correctly acknowledged that Aeneas’s treason was alleged by “the most ancient historians Dares [End Page 185] Phrygius and Dictys Cretensis” (Dictys, another late antique... (shrink)

The scientific study of consciousness in the late 19th century, which took place in Western countries across disciplines such as neurology, physiology, neuropathology, psychology, psychiatry and philosophy, appears to have striking parallels to current crossdisciplinary developments in the neurosciences. The 19th century period, however, has received little scholarly attention from historians of medicine, psychology, or science. Historians of depth psychology have investigated the area as part of the history of psychiatry, but cleaved most closely to the versions presented by early (...) psychoanalysts- turned-historians, who have consistently portrayed Freud as the only legitimate history of the period, thus marking the territory of the late 19th century as inherently Freudo-centric. More recently a new line of historiography emanating from the work of the late Henri Ellenberger has launched a post-Freudian perspective in which the classical depth psychologies of Freud, Jung, and Adler may now be understood in a wider and deeper historical context defined by the development of a so-called French, Swiss, English, and American psychotherapeutic axis between 1881 and 1918, before the advent of psychoanalysis. Chief among the prime movers of this axis was Frederic William Henry Myers, graduate of Cambridge University, and co-founder of the Society for Psychical Research in England in 1882. Myers' grasp of the literature of the day regarding the scientific study of consciousness was both profound, and highly influential, particularly on such figures as William James. Since the period itself has yet to be fully reconstructed, the identity of Myers and his contribution to the scientific study of consciousness remain obscure, but are also receiving new attention in the area of modern consciousness studies. (shrink)

The dominant position of science in our culture has ended. In our postmodern world, belief that science will provide the answer to our problems and that progress is inevitable has been shaken, if not toppled. Optimism has been replaced by realism, creating a milieu for the development of intelligent Christian belief. Participating in the Trinity Institute's conference on ÒThe Church in a Postmodern Age, these six prominent scholars explore the breakdown of the basic tenets of the Enlightenment, the sorry state (...) of biblical literacy in our culture, Christian faith in a pluralistic world, the relevance of the Bible today, and the role of the church in our age. Contributors include Robert N. Bellah, Diogenes Allen, George A. Lindbeck, James B. Miller, Sandra M. Schneiders, and Rowan D. Williams. (shrink)

La philosophie médiévale du langage présente deux séries d’affinités remarquables avec les approches contemporaines. L’une se situe du côté des sémantiques formelles et, plus généralement, des analyses logiques des conditions de vérité des énoncés. L’autre relève plutôt de la pragmatique, notamment des perspectives contextuelles sur les actes de langage. Les logiciens, grammairiens et théologiens du Moyen Âge étaient, de fait, pleinement conscients qu’ils avaient à leur disposition deux types d’approche des énoncés, selon qu’ils prenaient en compte les seules propriétés sémantiques (...) de leurs composants ou qu’ils intégraient des considérations extralinguistiques allant de l’intention des auteurs / locuteurs à leur statut, en passant par le contexte d’énonciation. Chacune de ces perspectives a bénéficié d’un certain nombre d’études récentes ; la question que je voudrais aborder est plutôt celle de leur frontière en logique, de son emplacement, ses déplacements, sa porosité éventuelle. La complexité des matériaux en jeu ne permettra pas de proposer plus que quelques points de repères, qui peuvent toutefois aider à évaluer l’hypothèse d’un « projet formel » en sémantique médiévale. (shrink)

Cet article a pour but de mettre en regard l’analyse de l’esprit de Hume avec les critiques de l’associationnisme qu’on faites William James et Henri Bergson à la fin du XIXe siècle, lorsqu’ils proposèrent de renverser l’ordre des genèses psychologiques : non pas association d’éléments atomiques séparés (les impressions et idées), mais dissociation de touts vagues confus (les expériences pures). Il cherche à montrer sur l’exemple de la perception de la ressemblance que Hume est sauf du reproche d’avoir ainsi (...) « atomisé » la vie mentale, ce que montre notamment la fonction sélective et donc discriminante du principe de ressemblance. Le commentaire de Deleuze qui voit dans le dualisme de l’atomisme et de l’associationnisme chez Hume le critère même de définition de l’empirisme en général s’en trouve de ce fait contesté. (shrink)

A lively and accessible history of Modernism, _The First Moderns_ is filled with portraits of genius, and intellectual breakthroughs, that richly evoke the _fin-de-siècle_ atmosphere of Paris, Vienna, St. Louis, and St. Petersburg. William Everdell offers readers an invigorating look at the unfolding of an age. "This exceptionally wide-ranging history is chock-a-block with anecdotes, factoids, odd juxtapositions, and useful insights. Most impressive.... For anyone interested in learning about late 19th- and early 20th- century imaginative thought, this engagingly written book (...) is a good place to start."—_Washington Post Book World_ "_The First Moderns_ brilliantly maps the beginning of a path at whose end loom as many diasporas as there are men."—Frederic Morton, _The Los Angeles Times Book Review_ "In this truly exciting study of the origins of modernist thought, poet and teacher Everdell roams freely across disciplinary lines.... A brilliant book that will prove useful to scholars and generalists for years to come; enthusiastically recommended."—_Library Journal_, starred review "Everdell has performed a rare service for his readers. Dispelling much of the current nonsense about 'postmodernism,' this book belongs on the very short list of profound works of cultural analysis."—_Booklist_ "Innovative and impressive... [Everdell] has written a marvelous, erudite, and readable study."-Mark Bevir, _Spectator_ "A richly eclectic history of the dawn of a new era in painting, music, literature, mathematics, physics, genetics, neuroscience, psychiatry and philosophy."—Margaret Wertheim, _New Scientist_ "[Everdell] has himself recombined the parts of our era's intellectual history in new and startling ways, shedding light for which the reader of _The First Moderns_ will be eternally grateful."—Hugh Kenner, _The New York Times Book Review_ "Everdell shows how the idea of "modernity" arose before the First World War by telling the stories of heroes such as T. S. Eliot, Max Planck, and Georges Serault with such a lively eye for detail, irony, and ambiance that you feel as if you're reliving those miraculous years."—Jon Spayde, _Utne Reader_. (shrink)

This is a translation from Bulgarian into English of Nikolai Lossky’s “Razlichniiat smisul na dumata intuitsiia” (“The Different Senses of the Word Intuition”), published in the Sofianite journal Filosofski pregled (Philosophical Review), 1931, year III, book 1, pp. 1–9. In this article, solicited by the journal’s editor-in-chief, the Bulgarian philosopher Dimitar Mihalchev, Lossky surveys the different ways in which the word “intuition” (intuitsiia) has been used throughout the history of philosophy: Kant, Fichte, Schelling, Hegel, Friedrich Jacobi, Ivan Kireevski, Alexei Khomyakov, (...) Vladimir Solovyov, Bergson, Husserl, and Hans Driesch. Lossky then situates his own use of the word within this philosophical tradition and compares his intuitivism with gnoseologies similar to his own, namely, those of Semyon Frank, Johannes Rehmke, Max Scheler, Paul Linke, Dimitar Mihalchev, the English realists (Samuel Alexander and John Laird), the American realists (Edwin Holt, Walter Marvin, William Montague, Ralph Perry, Walter Pitkin, and Edward Spaulding), and the Neo-Scholastic Josef Gredt. As such, the article makes a valuable addendum to his Obosnovanie intuitivizma (The Foundation of Intuitivism) (1906) and provides a helpful synopsis of his theory of knowledge, which, in accordance with the Russian terminological tradition, he calls “gnoseology”. (shrink)

This bibliography covers the Hume literature for 2003. Once again, I encourage readers of Hume Studies to supply additions, corrections, or bibliographical information still missing from any previous listings. I am grateful to all who have contributed additions or corrections to previous bibliographies, and again thank Frédéric Brahami for his help with this year’s French Hume literature.

For Quine, a paradox is an apparently successful argument having as its conclusion a statement or proposition that seems obviously false or absurd. That conclusion he calls the proposition of the paradox in question. What is paradoxical is of course that if the argument is indeed successful as it seems to be, its conclusion must be true. On this view, to resolve the paradox is (1) to show either that (and why) despite appearances the conclusion is true after all, or (...) that the argument is fallacious, and (2) if the former, to explain away the deceptive appearances. Quine divides paradoxes into three groups. A veridical paradox is one whose proposition or conclusion is in fact true despite its air of absurdity. We decide that a paradox is veridical when we look carefully at the argument and it convinces us, i.e., it manages to show us how it is that the conclusion is true after all and appearances to the contrary were misleading. Quine’s two main examples of this are the puzzle of Frederic in The Pirates of Penzance (who has reachError: Illegal entry in bfrange block in ToUnicode CMapError: Illegal entry in bfrange block in ToUnicode CMapError: Illegal entry in bfrange block in ToUnicode CMaped the age of twenty-one after passing only five birthdays), and the Barber Paradox, which Quine considers simply a sound proof that there can be no such barber as is described.1 A falsidical paradox is one whose proposition or conclusion is indeed obviously false or self-contradictory, but which contains a fallacy that is detectably responsible for delivering the absurd conclusion. We decide that a paradox is falsidical when we look carefully at the argument and spot the fallacy. Quine’s leading example here is De Morgan’s trick argument for the proposition that 2 = 1. (shrink)

Alexander Moritzi is one of the most obscure figures in the early history of evolutionary thought. Best known for authoring a flora of Switzerland, Moritzi also published Réflexions sur l’espèce en histoire naturelle, a remarkable book about evolution with an overtly materialist viewpoint. In this work, Moritzi argues that the generally accepted line between species and varieties is artificial, that varieties can over time give rise to new species, and that deep time and turnover of species in the fossil record (...) clearly support an evolutionary interpretation of biological diversity. Moritzi was also a gradualist and viewed relationships between taxa as best represented by a ramifying tree. Although Réflexions was the first full book to be written on the topic of evolution following Lamarck’s Philosophie zoologique, Moritzi’s evolutionist contribution was stillborn, read by almost no one in his lifetime and ultimately absent from the many historiographies of evolutionary thought. This is unfortunate since many of the arguments Moritzi marshaled on behalf of an evolutionary explanation of life can be found in subsequent transmutationist writings by Frédéric Gérard, Robert Chambers, Henri Lecoq, Baden Powell, Charles Naudin, Herbert Spencer, Alfred Russel Wallace, and Charles Darwin—none of whom is likely to have ever known of the existence of Réflexions. Finally, Moritzi’s arguments, along with those found in Darwin’s private essay on evolution of the same year, provide an excellent window into the state of evolutionary thought and debate over the nature of species at the beginning of the 1840s. (shrink)

Scholars of the nineteenth-century race sciences have tended to identify the period from c.1820– c.1850 as a phase of transition from philologically to physically focused study. In France, the physiologist William Frédéric Edwards (1776–1842) is normally placed near the center of this transformation. A reconsideration of Edwards’ oeuvre in the context of his larger biography shows that it is impossible to see a clear-cut philological to physical “paradigm shift.” Although he has been remembered almost solely for his principle of (...) the permanency of physical “types,” Edwards was also committed to what he recognized as the new science of “ linguistique” and proposed a new branch of comparative philology based on pronunciation. Bearing Edwards’ attention to linguistics in mind, this article reconstructs his racial theories in their intellectual contexts and suggests that at a time of emergent disciplinary specialization, Edwards tried to hold discrete fields together and mold them into a new “natural history of man.”. (shrink)

Frederic William Farrar was a cleric of the Church of England, schoolteacher and author. He was a pallbearer at the funeral of Charles Darwin in 1882. He was a member of the Cambridge Apostles secret society.

This new volume of the first critical edition of Bergson’s Oeuvres [2007-], directed by Frédéric Worms for the prestigious series Quadrige/Grand Textes of the Presses Universitaires de France, will be of particular interest for James’ scholars. Stéphane Madelrieux, who assembled together and edited the materials included in the volume, offers us the whole body of Bergson’s writings on James, and much more. In fact, besides the most famous introduction that le magicien Parisien wrote in 1911 f...

The concept of “magic realism” raises many problems, both theoretical and historical. I first encountered it in the context of American painting in the mid-1950s; at about the same time, Angle Flores published an influential article in which the term was applied to the work of Borges;1 but Alejo Carpentier’s conception of the real maravilloso at once seemed to offer a related or alternative conception, while his own work and that of Miguel Angel Asturias seemed to demand an enlargement of (...) its application.2 Finally, with the novels of Gabriel García Márquez in the 1960s, a whole new realm of magic realism opened up whose exact relations to preceding theory and novelistic practice remained undetermined. These conceptual problems emerge most clearly when one juxtaposes the notion of magic realism with competing or overlapping terms. In the beginning, for instance, it was not clear how it was to be distinguished from that vaster category generally simply called fantastic literature; at this point, what is presumably at issue is a certain type of narrative or representation to be distinguished from realism. Carpentier, however, explicitly staged his version as a more authentic Latin American realization of what in the more reified European context took the form of surrealism: his emphasis would seem to have been on a certain poetic transfiguration of the object world itself—not so much a fantastic narrative, then, as a metamorphosis in perception and in things perceived . In García Márquez, finally, these two tendencies seemed to achieve a new kind of synthesis—a transfigured object world in which fantastic events are also narrated. But at this point, the focus of the conception of magic realism would appear to have shifted to what must be called an anthropological perspective: magic realism now comes to be understood as a kind of narrative raw material derived essentially from peasant society, drawing in sophisticated ways on the world of village or even tribal myth. Recent debates, meanwhile, have complicated all this with yet a different kind of issue: namely, the problem of the political or mystificatory value, respectively, of such texts, many of which we owe to overtly left-wing revolutionary writers .3 In spite of these terminological complexities—which might be grounds for abandoning the concept altogether—it retains a strange seductiveness which I will try to explore further, adding to the confusion with reference points drawn from the work of Jacques Lacan and from Freud’s notion of the “uncanny,” and compounding it by an argument that magic realism is to be grasped as a possible alternative to the narrative logic of contemporary postmodernism.4 1. See Angel Flores, “Magical Realism in Spanish American Fiction,” Hispania 38 : 187-92.2. See Alejo Carpentier, “Prólogo” to his novel El Reino de este mundo ; the most useful survey of the debate remains Roberto Gonzalez Echeverria, “Carpentier y el realism magico,” in Otros Mundos, otros fuegos, ed. Donald Yates, Congreso International de Literature Iberoamericana 16 , pp. 221-31.3. See Angel Rama, La Novel en America Latina , and especially Carlos Blanco Aguinaga, De Mitólogos y novelistas , in particular the discussions of Gabriel García Márques and Alejo Carpentier.4. My own general frame of reference for “postmodernism” is outlined in my “Postmodernism; or, The Cultural Logic of Late Capitalism,” New Left Review 146 : 53-92. Frederic Jameson, William A. Lane Professor of Comparative Literature at Duke University, is the author of The Prison-House of Language and The Political Unconscious: Narrative as a Socially Symbolic Act. He is also a member of the editorial collective of Social Text. His previous contributions to Critical Inquiry are “The Symbolic Inference; or, Kenneth Burke and Ideological Analysis” and “Ideology and Symbolic Action”. (shrink)

William James's The Varieties of Religious Experience is one of the world's most popular attempts to meld science and religion. Academic reviews of the book were mixed in Europe and America, however, and prominent contemporaries, unsure whether it was science or theology, struggled to interpret it. James's reliance on an inherently ambiguous understanding of the subconscious as a means of bridging between religion and science accounts for some of the interpretive difficulties, but it does not explain why his overarching (...) question was so obscure, why psychopathology and unusual experiences figured so prominently, or why he gave us so many examples and so little argument. To understand these persistent puzzles we need to do more than acknowledge James's indebtedness to Frederic Myers's conception of the subconscious. We need to read VRE in the context of the transatlantic network of experimental psychologists and psychical researchers who provided the primary intellectual inspiration for the book. Doing so not only locates and clarifies the underlying question that animated the work but also illuminates the structural and rhetorical similarities between VRE and Myers's Human Personality and Its Survival of Bodily Death. In contrast to the individual case studies of hysterics, mediums, and mystics produced by others in this network, both Myers and James adopted a natural-history approach in which they arranged examples of automatisms to produce a rhetorical effect, thus invoking science in order to evoke a religious response. Where Myers organized his examples to make a case for human survival of death, James organized his to make a case for the involvement of higher powers in the transformation of the self. Read in this way, VRE marks a dramatic shift from a religious preoccupation with life after death to a religious preoccupation with this-worldly self-transformation. (shrink)

The idea that deep brain stimulation (DBS) induces changes to personality, identity, agency, authenticity, autonomy and self (PIAAAS) is so deeply entrenched within neuroethics discourses that it has become an unchallenged narrative. In this article, we critically assess evidence about putative effects of DBS on PIAAAS. We conducted a literature review of more than 1535 articles to investigate the prevalence of scientific evidence regarding these potential DBS-induced changes. While we observed an increase in the number of publications in theoretical neuroethics (...) that mention putative DBS-induced changes to patients’ postoperative PIAAAS, we found a critical lack of primary empirical studies corroborating these claims. Our findings strongly suggest that the theoretical neuroethics debate on putative effects of DBS relies on very limited empirical evidence and is, instead, reliant on unsubstantiated speculative assumptions probablyin lieuof robust evidence. As such, this may reflect the likelihood of a speculative neuroethics bubble that may need to be deflated. Nevertheless, despite the low number of first-hand primary studies and large number of marginal and single case reports, potential postoperative DBS changes experienced by patients remain a critical ethical concern. We recommend further empirical research in order to enhance theoretical neuroethics work in the area. In particular, we call for the development of better instruments capable of capturing potential postoperative variations of PIAAAS. (shrink)

The phenomenological effects of deep brain stimulation (DBS) on the self of the patient remains poorly understood and under described in the literature, despite growing evidence that a significant number of patients experience postoperative neuropsychiatric changes. To address this lack of phenomenological evidence, we conducted in-depth, semistructured interviews with 17 patients with Parkinson's disease who had undergone DBS. Exploring the subjective character specific to patients' experience of being implanted gives empirical and conceptual understanding of the potential phenomenon of DBS-induced self-estrangement. (...) Our study concluded that (1) the more patients preoperatively felt alienated by their illness, the more they experienced postoperative self-estrangement, and (2) the notion of self-estrangement seems to exist in association with certain common qualitative characters, namely, loss of control, which reflects a deteriorative estrangement, and distorted perception of capacities, which reveals a restorative estrangement. These findings indicate that subjective self-reports help us to understand some aspects of the potential phenomenon of DBS-induced self-estrangement. (shrink)

The intersection of AI and neurotechnology has resulted in an increasing number of medical and non-medical applications and has sparked debate over the need for new human rights, or “neurorights,”...

Deep brain stimulation (DBS) has been regarded as an efficient and safe treatment for Parkinson’s disease (PD) since being approved by the Food and Drug Administration (FDA) in 1997. It is estimated that more than 150 000 patients have been implanted, with a forecasted rapid increase in uptake with population ageing. Recent longitudinal follow-up studies have reported a significant increase in postoperative survival rates of patients with PD implanted with DBS as compared with those not implanted with DBS. Although DBS (...) tends to increase life expectancy for most patients with PD, this medical benefit does not come without attendant negative consequences. For example, emerging forms of iatrogenic harms are sometimes induced—harms which were not initially expected when clinicians proposed neurosurgery and patients or their guardians consented to the treatment. We report and discuss the clinical case of a patient who was implanted with DBS more than 20 years ago (at the time of writing) and is now experiencing unexpected stages of PD. This case illustrates how extending the life span without improving quality of life may introduce a burden of harms for patients and families. As well, this case shows why we should prepare for the expanding numbers of PD-implanted patients experiencing a gain of longevity but with severe stages of disease leading to diminution in quality of life. This newly observed effect of DBS treatment requires us to explore ethical questions related to iatrogenic harms, informed consent, end of life and caregivers’ burden. (shrink)

Optogenetics is being optimistically presented in contemporary media for its unprecedented capacity to control cell behavior through the application of light to genetically modified target cells. As such, optogenetics holds obvious potential for application in a new generation of invasive medical devices by which to potentially provide treatment for neurological and psychiatric conditions such as Parkinson's disease, addiction, schizophrenia, autism and depression. Design of a first-in-human optogenetics experimental trial has already begun for the treatment of blindness. Optogenetics trials involve a (...) combination of highly invasive genetic and electronic interventions that results in irreversible and permanent modifications of an individual's nervous system. Given its novelty, its uncertain benefit to patients, and its unique risk profile of irreversible physiological alteration, optogenetics requires a reassessment of the ethical challenges for protecting human participants in clinical trials, particularly at formative stages of clinical evaluation. This study explores the evolving ethical issues surrounding optogenetics’ potential harm to participants within trial design, especially focusing on whether Phase 1 trials should incorporate efficacy as well as safety endpoints in ways that are fair and respectful to research trial participants. (shrink)

A major philosophical mind in his day, William Paley wrote in a lucid style that made complex ideas more accessible to a wide readership. This work, first published in 1785, was based on the lectures he gave on moral philosophy at Christ's College, Cambridge. Cited in parliamentary debates and remaining on the syllabus at Cambridge into the twentieth century, it stands as one of the most influential texts to emerge from the Enlightenment period in Britain. An orthodox theologian, grounding (...) his utilitarian ethics in strong religious faith, Paley held notably progressive views on issues of toleration and the slave trade. His perspicuity prompted one contemporary to remark that the book 'presents a subject which has always been considered as harsh and difficult, in the most agreeable and intelligible form … we sit down to be informed of our duty, and are surprised to meet with amusement'. (shrink)

One important concern regarding implantable Brain Computer Interfaces is the fear that the intervention will negatively change a patient’s sense of identity or agency. In particular, there is concern that the user will be psychologically worse-off following treatment despite postoperative functional improvements. Clinical observations from similar implantable brain technologies, such as deep brain stimulation, show a small but significant proportion of patients report feelings of strangeness or difficulty adjusting to a new concept of themselves characterized by a maladaptive je ne (...) sais quoi despite clear motor improvement. Despite the growing number of cases in the DBS literature, there is currently no accepted or standardized tool in neuroethics specifically designed to capture the phenomenological postoperative experience of patients implanted with DBS or BCI devices. Given potential risks of postoperative maladaptation, it is important for the field of neuroethics to develop a qualitative instrument that can serve as a shared method for capturing postoperative variations in patient experience of identity and agency. The goal of this article is to introduce an instrument we have developed for this purpose and call for further neuroethical efforts to assess the phenomenology of implantable brain device use. (shrink)

In their article, Herrera-Ferra et al. (2023) highlight how the progress and implementation of neurotechnology, especially in conjunction with artificial intelligence, have revealed potential impli...

Bioethics, Volume 36, Issue 1, Page 25-41, January 2022.